Simulations are highly effective learning tools based on the foundations of neuroscience, brain-based learning theory, and neuropedagogy. Simulations and gamifications result in greater student involvement and knowledge retention than conventional instruction. In 2018, a pilot program was launched in the Emergency and Disaster Management program at American Military University in which traditional readings, lectures, and text were replaced with simulations. Various student performance measures were analyzed and showed improvement over the traditional method of instruction, and it was concluded that these improvements were due to the nature of the simulations. The greater use of simulations in education will enhance the quality of instruction and develop students’ cognitive skills.